When funding policy advocacy in the rich world, Open Philanthropy Project aims to only fund projects that at least meet the '100x bar', which means that the things they fund need to increase incomes for average Americans by $100 for every $1 spent to get as much benefit as giving $1 to GiveDirectly recipients in Africa. The reason for this is that (1) there is roughly a 100:1 ratio between the consumption of Americans to GiveDirectly cash transfer recipients, and (2) the returns of money to welfare are logarithmic. A logarithmic utility function implies that $1 for someone with 100x less consumption is worth 100x as much. Since GiveWell's top charities are 10x better than GiveDirectly, the standard set by GiveWell's top charities is a '1,000x bar'.
Since 2015, Open Phil has made roughly 300 grants totalling almost $200 million in their near-termist, human-centric focus areas of criminal justice reform, immigration policy, land use reform, macroeconomic stabilisation policy, and scientific research. In 'GiveWell’s Top Charities Are (Increasingly) Hard to Beat', Alex Berger argues that much of Open Phil's US policy work probably passes the 100x bar, but relatively little passes the 1,000x bar.
The reason that Open Phil's policy work is able to meet the 100x bar is that it is leveraged. Although trying to change planning law in California has a low chance of success, the economic payoffs are so large that the expected value of these grants is high. So, even though it is a lot harder to increase welfare in the US, because the policy work has so much leverage, the expected benefits are high enough to 100x the $ benefits.
This raises the question: if all of this true, wouldn't advocating for improved economic policy in poor countries be much better than GiveWell's top charities? If policy in the US has high expected benefits because it is leveraged, then policy in Kenya must also have high expected benefits because it is leveraged. We should expect many projects improving economic policy in Kenya to produce 100x the welfare benefits of GiveDirectly, and we should expect a handful to produce 1,000x the welfare benefits of GiveDirectly.
This is an argument for funding work to improve economic policy in the world's poorest countries. Lant Pritchett has been arguing for this position for at least 7 years without any published response from the EA community. Hauke Hillebrandt and I summarise his arguments here. My former colleagues from Founders Pledge, Stephen Clare and Aidan Goth, discuss the arguments in more depth here.
Updated addendum: At present, according to GiveWell, the best way to improve the economic outcomes of very poor people is to deworm them. This is on the basis of one very controversial RCT conducted in 2004. I don't think this is a tenable position.

Thanks for the reply. I'll have to answer it... it was supposed to be short, I really didn't have the time, but then I started enjoying it. But I have a TL;DR.
TL;DR: I guess we’re not understanding each other very well, as you seem to be responding to other people (unfortunately, because I’m a big fan). I don’t see why you categorize me as a skeptic. I think we actually agree (i) RCT shouldn’t be the main path for dev-eco researchers, and (ii) there should be more research focused on developing countries. But: (iii) development economics is more complex than you make it look like, (iv) I keep the discussion on dev-eco research apart from the discussion on which cause areas to choose. Also, please, take a charitable look at my answer to your point (5)... but I don’t see how you can talk about Rwanda’s growth after 94 without talking about genocide and war.
Congrats 😉 on the other hand, like many people who commented on the subject, I upvoted your post back then, but I don’t find your case against randomistas so persuasive; I don’t upvote only posts I agree with – but if this is sending the wrong signals, perhaps I should start down-voting more.
Actually, I think your constant emphasis on Pritchett (as if the argument for dev-eco depended on him) is one of the weakest points of the post.
Also, five economists who disagree a lot about how development can be achieved. For instance, Acemoglu emphasizes the role of culture and institutions (but I think Melissa Dell research makes an even better case for this), but then Hausmann, Pritchett and Rodrik (2004) say, in the same article, that “Political-regime changes” and “economic reform” are “significant predictors of growth acceleration,” even though “the vast majority of growth accelerations are unrelated to standard determinants such as political change and economic reform, and most instances of economic reform do not produce growth accelerations.”
Also, Rodrik (my favorite one among them) claimed globalization (with free capital flows), national sovereignty and democracy are incompatible, defended an industrial policy approach to growth for a while, but admitted, in an interview with Tyler Cowen in 2015 (I recommend it), that the window for policies based on East Asia growth is likely gone; also in the same interview, he predicted Brazil would return to growing faster than India again – which didn’t happen (I mean, it’s sad for me, a Brazilian, to here it today).
I’m not sure what’s the problem here and what sort of response you’re expecting. But as mentioned before, you also received a lot of comments, many of them discussing some of your main points; and you cite Founder’s Pledge analysis of the area, which concludes (very persuasively, in my opinion) that “We’re not continuing this project because we think identifying funding opportunities would be too costly for us and for the organisations under consideration.”
Perhaps you’re victims of your own success, since searching for “randomista” in the EA Forum mostly leads to references to your post – but it shows people are actually taking it into account; I think it might provide some sort of middle ground between short-term and longterm causes). But, yeah, the only thing that seems as deep as your original post is K. Sarek’s long summary of Ogden’s “RCTs in Development Economics.”
However, I must add that I think EA is more often identified with randomista economics by outsiders – precisely because RCTs in economics provide a useful rhetorical advice to distinguish EA from other approaches to philanthropy.
I’m sorry, but calling my position scepticism is getting too close to a strawman – an unfortunately common move among us philosophers, as if it’s impossible to engage with someone without putting a tag on them. For instance, you don’t call someone who says “people disagree about cancer” a skeptic. I explicitly said economic development is very important, and I don’t deny we know a lot about it, nor that people should research it (quite the opposite); I’m just claiming that arriving to specific recommendations on growth, at the required scale, is way harder than you make it look like (particularly if we restrict the discussion to a small sample of economists, in a limited period of time). If I'm skeptical about anything, it is that we will figure out something like a feasible way to, e.g., make Haiti grow like Botswana did, or even to ensure the latter keeps its current trajectory for decades.
Also, I suspect there’s a widespread Dunning-Kruger effect in discussions about economics, where experts usually express themselves with way less confidence than the average amateur. So, I’m not saying we’re in the dark here – actually, we are more likely being obfuscated by too much noisy light. Thus, sorry, but I think your “replies to skepticism” are answering the wrong man (unfortunately, I’d like it to be me, as I’m a big fan of your work), and I’m afraid we’re not quite understanding each other.
On the other hand, I feel compelled to answer in full, as you do provide me with some examples I can target:
Actually, I don’t see why this is impossible.
However, I must remark: I think we actually agree economic researchers should focus more on developing countries, right?
I agree these examples show problems that could be fixed with simple recommendations from economics. Do you think there’s any initiative which is likely to lead to these intended outcomes? What do you think its cost-effectiveness could be? I'd gladly know more about it.
But notice they're very different issues, and they're more like symptoms than causes of the underlying conditions affecting these nations. I don’t think the problem here is anything like a lack of economic literacy, or advocacy for the right economic policies – it’s more things like inadequate equilibria.
I think this remark is surprising, because it totally ignores my point on the Nurkse v. Hirschman debate, which is my very example of how these discussions are still unsettled. And even now, we still don’t really know, e.g, what kickstarted the Industrial Revolution in England, but we do know economists back then were wrong about many things – even though economies have increased exponentially since then.
4) I don't think there's any point in answering (4), as it seems premised on the accusation of broad skepticism. I agree that finding out, e.g., how to make everyone grow like Botswana would be huge. Except that perhaps you're framing the problem in a way that underestimates the costs of obtaining new information here. Again, development economics has been a hot topic for a long time.
I’d first try to avoid another Rwandan genocide and the following Congo Wars, which are among the worst things that have happened in the world in the last 30 years. Seriously.
My point is not the rhetorical effect of “how could you forget that?”, but that any explanation of Rwanda’s growth after 1994 that fails to take it into account is likely flawed. WorldBank’s overview of the country refers it explicitly, for instance.
6) I will answer this separately. It’ll take longer, and, unfortunately, I’m not paid to do this – quite the opposite, perhaps.
Well, this is the debate I actually want to have – and I guess you do, too. Dufflo and Banerjee response to this would be (in my interpretation from Good Economics for Hard Times: Better Answers to Our Biggest Problems) that we know more about how to make progress in this area (RCT), and that researchers can learn useful stuff with that (which might provide positive feedback loops); besides, we already had, and will keep having, public policies that will need to be oriented by research.
They have a point, but I agree with you (as I said before) this is likely not the best approach to development – as it is more about redistributing resources than creating them (i.e., growth), and it still leaves a huge blank in our theory of dev-eco. But this is about the roads economic researchers are trailing, not about EA recommendations.
8) This scared me a bit, too. But you have to read into the whole context. They're emphasizing the need to change consumption patterns (particularly in developed countries), because energy-efficiency programmes failed to deliver results, and so recognizing there's a trade-off here (and pending towards lowering emissions). They are not against growth. But I got scared: what if Cowen's "Crusonia plants" are getting harder to find?
Neglectedness
I’d like to see someone investigate it more thoroughly. I agree US policy is not neglected. But I guess neglectedness is more about opportunity costs: how much do you expect the counterfactual effect of more input on this area to be? What will it add? Will it crowd-in or crowd-out additional investment?
(You know, this is analogous to a very controversial point on the role of the State in dev-eco since at least Nurkse: will a state intervention here crowd-out or crowd-in private investments?)
Finally, summarising my point: some of the best minds in economics are already taking dev-eco seriously, funded by governments and wealthy organizations, and things are still quite uncertain when it comes to feasible particular recommendations – as my future answer concerning my own country (I’ll see what I can say, despite a small but positive risk of suffering future persecution - sorry, but paranoia is starting to spread around) might exemplify. But I agree with you that sending 30% of economic researchers to do RCTs on things like transfers is likely a wrong move.